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Research on neurodegenerative, neuroinflammatory, and neuro-oxidative stress in related brain diseases revealed that genetic and environmental factors affect Trx function and that the Trx system may be an important target for disease intervention and treatment (Bjrklund et al., 2022)

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It has been reported that by inhibiting phosphorylation of serine 10 in this pathway, breast cancer cells simultaneously challenged with estradiol show an overproduction of ROS, with increased oxidation of the DNA that overwhelms the repair apparatus and triggers PCD in a great percentage of these cells 144 (Fig