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The activation of human CD4 + T cells that depend on CD3/CD28 signaling promote GLS expression (46)

However, the underlying molecular mechanism of ferroptosis in AD, when ferroptosis occurs in the disease course, and which ferroptosis-related genes are differentially expressed in AD remains to be established

Bio-Rad, Hercules, CA, USA) with Image Lab Software 3.0

Future research should integrate multi-omics technologies with longitudinal clinical cohorts to define therapeutic windows and inter-individual variations in PRLMs responses, identify predictive biomarkers, and explore combinatorial strategies with established metabolic interventions, such as GLP-1 receptor agonists and SGLT2 inhibitors

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