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Terpenoids, including ginsenosides, geniposides, and andrographolide, bolster hepatoprotective and neuroprotective mechanisms through the activation of phase I/II detoxification enzymes and neutralization of reactive oxygen species (ROS)

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An inactive enzyme without the cofactor is called an apoenzyme, while the complete enzyme with cofactor is called a holoenzyme

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Sawane M, Kajiya K, Kidoya H, Takagi M, Muramatsu F, Takakura N (2013) Apelin inhibits diet-induced obesity by enhancing lymphatic and blood vessel integrity