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Description

Mild dehydration can lead to constipation and stool that's darker brown and harder than normal

Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, Angenendt P, et al

Nrf2, a key endogenous antioxidant transcription factor, is activated by the dissociation of the Keap1 protein, subsequently entering the nucleus to regulate the expression of antioxidant genes in conjunction with ARE elements (Vriend and Reiter, 2015)