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Furthermore, compounds such as acteoside and emodin, derived from natural plant sources, are recognized for their heat-clearing and detoxifying effects

including a decrease in GABA and an increase in glutamate

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191 Besides, LSD2 also has E3 ubiquitin ligase activity, which can promote the proteasome degradation of O-GlcNAc transferase and inhibit the growth of lung cancer A549 cells