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Long-term exposure to pro-oxidants causes oxidative stress, which affects cellular structure, mitochondrial DNA, and functioning enzymes

Food Res Int 51:123131 Pascual O, Vignault A, Gombau J, Navarro M, Gmez-Alonso S, Garca-Romero E, Canals JM, Hermosn-Guterrez I, Teissedre PL, Zamora F (2017) Oxygen consumption rates by different oenological tannins in a model wine solution

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Because therapeutic window of H 2 S is narrow, to clarify how changes in balance of H 2 S production and catabolism play in illness must lead to further strategy of H 2 S-based therapies