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76 In a cell experiment, when renal tubular cells experienced hypoxia and then reoxygenation, the levels of HIF-1 and BNIP3 were increased, mediating mitophagy, which could protect cells from cell apoptosis

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Then, we generated an acquired cetuximab-resistant cell line, Caco-2-CR, which could be cultured in medium supplemented with 200 g/ml cetuximab by chronically exposing Caco-2 cells to increasing concentrations of cetuximab for more than six months (Fig

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