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This decline is attributed to the slower turnover rate of splenic B cells in aged mice, allowing them to survive longer and signaling to newly generated B cells that peripheral niches are fully occupied [347, 348]

J Neurochem 13:655669 Gotthardt JD, Verpeut JL, Yeomans BL, Yang JA, Yasrebi A, Roepke TA, Bello NT (2016) Intermittent fasting promotes fat loss with lean mass retention, increased hypothalamic norepinephrine content, and increased neuropeptide Y gene expression in diet-induced obese

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Prior therapeutic interventions have targeted HDL-C levels and not metrics of HDL function

Citrulline produces nitric oxide (NO) that is broken down in a couple of seconds