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Glutathione S-transferases (GSTs) catalyze the conjugation of GSH to a broad range of electrophilic compounds, including endogenous signaling molecules, reactive aldehydes such as 4-hydroxynonenal (4-HNE), and heavy metals 13,14

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Yet, several cases of skin irritation, allergic contact dermatitis, and eczema have been reported with the use of dexpanthenol-containing ointments (45-49)

Alpha-lipoic acid attenuates cerebral ischemia and reperfusion injury via insulin receptor and PI3K/Akt-dependent inhibition of NADPH oxidase