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doi: 10.1016/S1474-4422(07)70104-7 30 AlpertJEMischoulonDNierenbergAAFavaM

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Mitochondrial damagecaused by membrane depolarization, mPTP (Mitochondrial permeability transition pore) opening, or BAK/BAX (BCL-2 homologous antagonist/killer and BCL-2-associated X protein) macropores formation allows mtDNA to escaple into the cytosol, where it functions as a potent DAMP (Damage-associated molecular pattern) ( 4.2 Mechanisms of HIV/SIV-induced mtDNA damage and dysfunction HIV uses both direct and indirect mechanisms that compromise mtDNA integrity and mitochondrial function

Reader proteins that recognize m 7 G modifications include eIF4E, QKI, and NCBP2, which are involved in regulating RNA maturation, nuclear export, and translation processes