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In other words, postauricular delivery concentrated the drug in the labyrinth for an extended period, implying enhanced efficacy and reduced systemic risk

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In a study of 53 patients with rheumatoid arthritis receiving infliximab, the prevalence of antinuclear antibody at a dilution greater than 1:100 increased from 24% at baseline to 77% at 30 weeks and 69% at 54 weeks