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Glutathione can exist intracellularly in either an oxidized (glutathione disulfide) or reduced (glutathione) molecular state

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8226/S, 8226/S-CR, 8226/S-ATOR05 cells were treated with 2 M ATO for 0, 6, or 24 h, protein expression was determined by Western blot and membranes were probed with antibodies against proteins involved in the (A) antioxidant response or (B) the Bcl-2 family

The type II form is caused by mutation in the NFC2 gene which encodes the p67-PHOX (phagocyte oxidase) protein

Patient-derived fibroblasts were also used to study expression and electrical activity of Ca 2+ activated K + channels (K Ca 1.1) and pro-inflammatory cytokine expression [39]