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One of the principal molecular regulators of such defense is the Nrf2antioxidant response element (ARE) signaling axis, which orchestrates antioxidant and cytoprotective gene expression programs [251]

Studies examining chronic obstructive pulmonary disease (COPD) reveal GHK's ability to reverse pathological gene expression signatures

doi: 10.3390/molecules26071993 84

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Gut microbiota metabolites 1,3-diaminopropane and reuterin were considered key factors in reducing iron absorption by suppressing HIF-2 activity and upregulating the iron-storage protein ferritin, thereby alleviating systemic iron overload [162]