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Injections commenced 12 h pre-ischemia and repeated every 24 h until sacrifice at 72 h post-reperfusion

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In particular, ROS, which are partially reduced metabolites of oxygen consumption, may contribute to alveolar-capillary membrane disturbances and the development of lung injury [5, 8, 10, 22, 35]

This finding indicates that ferritin is a major source of iron for meningococci during cellular infection, a hypothesis supported by evidence that: i