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Colonic inflammation in mice is induced by GABAR subunit 3 (3-GABAR) agonist, while ligands targeting 1/4/5-GABAR decrease the expression of colonic inflammatory markers [112]

Zhang J, Guo P, Qiu M, Zhong G, Yang Q, Lei P, Gou K, Zeng R, Zhang C, Qu Y

Similarly, CD38 inhibitors, such as 78C, protect against cardiomyocyte senescence by preserving NAD+ [19]

If the leaky gut or systemic inflammation returns immediately during the washout, it suggests that the root cause (such as diet or chronic stress) has not been addressed, and the peptides are merely masking the symptoms [3, 8]

While in the present study we did not include a group of untreated 5xFAD mice, our previous experience revealed no differences between untreated and IgG-injected mice, neither in the 5xFAD 54 nor DM-hTAU 40 mouse models

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