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Fisher CL, Cabelli DE, Hallewell RA, et al

Common and clinically significant side effects include gastrointestinal discomfort, nausea, flushing, persistent lymphopenia, and, in rare cases, treatment-associated progressive multifocal leukoencephalopathy (PML) (Naismith et al., 2020

Figure 6 Altogether, the results indicated that LA protected the kidney from FA-induced oxidative stress damage, which may be closely related to the maintenance of the antioxidant defenses system

In 1977, an expert panel convened by the FDA issued urgently worded advice, saying it was obligatory to put a warning on the drugs label that it could cause severe liver damage. After much debate, the FDA added the warning 32 years later

This increase in absorption suggests that quercetin glucoside facilitates interaction with epithelial glucose transporters, leading to a more rapid uptake and improved bioavailability of glucosides following ingestion ( The biodegradation of larger flavone molecules into more minor, low molecular weight compounds is necessary to cross the intestinal epithelium

However, clinical experience with this drug remains limited