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The study implemented a survey that found sirolimus users reported high perceived quality of life and good health status but given the nature of the study specific health outcomes were difficult to measure.12 With regards to dosing for longevity, though comparative data is limited, some believe that an intermittent sirolimus dosing schedule could result in fewer adverse events than everyday dosing

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Clin Exp Pharmacol Physiol 46:10011012 Zhao T, Chen S, Wang B, Cai D (2020) L-carnitine reduces myocardial oxidative stress and alleviates myocardial ischemia-reperfusion injury by activating nuclear transcription-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway

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The lysosomal acid sphingomyelinase SMPD1 appeared to be the most specific to senescence