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Pretreatment with galangin in ISO-induced rats lowers heart rate, lipid peroxidation, and blood pressure

These enzyme complexes act to incorporate an atom of oxygen into nonactivated hydrocarbons, which can result in either the introduction of hydroxyl groups or N-, O- and S-dealkylation of substrates

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Specifically, genomic instability characteristic of many cancers including GBM elicit engagement of the cyclic guanosine monophosphate (GMP) adenosine monophosphate (AMP) synthase (cGAS)- stimulator of IFN genes (STING) pathway which prompts secretion of type one interferon (IFN) into the TME [154, 155]

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In biological environments, carotenoids have been shown to effectively block this chain reaction at low oxygen pressure [150]