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Readers should treat this article as context for documentation review

10.1093/qjmed/hcn138

HF is indeed associated with profound perturbations of mitochondrial life cycle partly due to down-regulation of PGC-1 and its downstream target genes, which control the renewal of the mitochondrial pool of cardiomyocytes [132], thereby leading to the accumulation of mitochondrial defects reported in the failing myocardium