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Chronic infections, including those caused by Helicobacter pylori and Mycobacterium tuberculosis , exploit mitochondrial manipulation to facilitate long-term persistence within the host, thereby evading immune clearance ( Therapeutic strategies designed to counteract pathogen-induced mitochondrial dysfunction focus on restoring mitochondrial integrity and immune balance

(PubMed) Sherman PM, Ossa JC, Johnson-Henry K

High cholesterol levels promote interactions between the endoplasmic reticulum (ER) and mitochondria in CD8 + T cells, causing CD8 + T cell disruption and exhaustion of mitochondrial activity in colorectal cancer [74]

10.1016/j.biopha.2022.112951 54 KieliszekM

This generates large amounts of superoxide and ROS, which react with pathogens in phagosomes and trigger an inflammatory response (62)