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138 In this trial, PF-06823859 150 mg and 600 mg IV every 4 weeks both met the primary endpoint of significantly decreasing CDASI-A scores at 12 weeks compared with placebo

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Klein RL, Muir D, King MA, Peel AL, Zolotukhin S, Mller JC, Krttgen A, Heymach JV , Muzyczka N, Meyer EM

It produces neuroadaptive responses at both serotoninergic and dopaminergic level coherently with the development and maintenance of MDMA self-administration in some experimental animals and the development of a substance misuse in some humans

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Most users drop to 40-60% lower maintenance doses