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Meanwhile, the histones contain a flexible N-terminus, often named the histone tail [17], which can undergo various combinations of PTMs, dynamically allowing regulatory proteins access to the DNA to fine tune almost all chromatin-mediated processes including chromatin condensation, gene transcription, DNA damage repair, and DNA replication [18] (Fig

Crystal structure of the tyrosine kinase domain of the human insulin receptor

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Introduction MS is a neurodegenerative disorder that results in permanent neurological impairment due to axonal damage