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Contextual Variables Published dosing patterns are influenced by factors such as: body weight of the research model species differences (rodent vs in-vitro systems) delivery method measurement endpoints (angiogenesis, fibroblast activity, inflammation markers, etc.) These variables limit direct comparison between studies

After anaesthesia they were perfused with heparinised saline solution (0.9%) followed by 4% paraformaldehyde in 0.2 M PBS

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Stefek 2011)

Components of this microenvironment, such as the extracellular matrix, regulate the expression of apoptosis-related proteins in AML cells, affecting their sensitivity to chemotherapy (90)