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The xenobiotic adaptation in arthropods evolves through multiple mechanisms (Figure 1) [13, 14], including reduced penetration through the cuticle, behavioral avoidance [15, 16], microbiome-mediated detoxification [17-20], enhanced metabolic detoxification [21-25], enhanced sequestration or excretion [13, 19, 26, 27], and target site insensitivity [28-32]

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The AITC concentrations used were 50 M, 100 M, 300 M and 500 M, based on our recent study on the effect of AITC on root growth inhibition 74

This permits the measurement of the two major metabolic pathways, oxidative phosphorylation, represented by oxygen consumption rate (OCR), and glycolysis, represented by extracellular acidification rate (ECAR) in live cells in real-time

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While the underlying mechanisms of memory loss and cognitive impairment in bipolar disorder remain uncertain, these data indicate that defects in CaMKK2-CaMK1 signalling may play a role