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Studies of the mechanisms of action of DBS have mostly focused on basal ganglia thalamocortical circuits in animal models and patients with PD

Inhibiting SEH has been effectively used to lower BP, reduce HTN-related kidney damage, and minimize infarction size in animal models

However, a few studies have suggested that these actions of the trefoil peptides may also contribute to the movement of cancer cells, known as metastasis, in cell models

In the wound environment, it is a chemoattractant for inflammatory and endothelial cells

Dvok J, Delcroix M, Rossi A, Voplensk V, Pospek M, edinov M, et al