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The extent to which GSH was increased in each tissue varied, with the kidney and the lung exhibiting the greatest increase in GSH abundance compared to those from GshF -null mice

In clinical practice, however, high doses of GCs are still often used, causing substantial co-morbidity

Second, the tissue-specific differences in FA metabolism, where FA metabolism in various organs, such as the liver and kidneys, influences distinct stages of GA progression, and the varying tissue affinities exhibited by drugs, such as the PPAR agonists pioglitazone (113) and aleglitazar (240), exhibit stronger affinity for the hepatic tissue, redistributing visceral fat to peripheral tissues

& Sandhir, R

The once-weekly injection schedule is both sufficient for maintaining therapeutic levels and the only regimen with clinical safety data supporting it