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Moreover, studies have demonstrated that TMAO plays a role in promoting inflammatory responses and oxidative stress in the body, which are critical factors in the advancement of kidney disease

Am.J Hypertens

Specifically, astrocytes in the striatum use fatty acids, and those in the cerebellum use amino acids, but this may lead to oxidative stress (Hu and Kong 2022

Huang, H., Song, L., Zhang, H., Zhang, J

In vivo , the use of FMO3-KO mice colonized with humanized microbiota via fecal transplant provided a physiologically relevant model for human TMA metabolism