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Longevity context, not a shortcut MIC-B12 sits within a broader longevity approach rather than acting as a standalone fix

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Ravikumar et al., 2010) reveal abnormal cleavage of PICALM in AD brains, with significantly reduced 75 kDa PICALM levels, disrupted cathepsin D (Cath D) processing, and impaired lysosomal function, leading to autophagy deficits and inhibited Tau degradation

Lancet 375:12551266 Loane C, Politis M (2012) Buspirone: what is it all about

Moreover, circadian disruption has been associated with an increased susceptibility to acute kidney injury (AKI), underscoring the importance of rhythmicity in maintaining renal health (Motohashi et al., 2020)