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The peptide specifically upregulates genes for both type I collagen, which provides structural strength, and type III collagen, which contributes to tissue flexibility and elasticity

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The following have been shown to shift estrogen metabolism toward the 2-hydroxyestrone pathway[2]: Exercise and weight loss Isoflavones such as soy and flaxseed Omega-3 fatty acids Green tea polyphenol Cruciferous vegetables and broccoli derivatives, including indole-3-carbinol (I3C) and diindolylmethane (DIM, result of I3C after activation by stomach acid) A healthy lifestyle that allows for a normal weight helps to decrease the risk of insulin resistance from metabolic syndrome

But, how well they work can depend on the condition and the persons health

By acting as an enzyme inhibitor within fat cell metabolism, these peptides might influence the reduction of white adipose tissue