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doi: 10.1016/j.cgh.2012.08.012

The brain, consuming approximately 20% of the oxygen needed for survival, is particularly vulnerable to attack by free radicals

Lindqvist U, Laurent TC

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showed that AS-IV activates the PI3K/AKT/Nrf2/ARE signaling pathway, enhancing Nrf2 expression and nuclear translocation, binding to the ARE upstream, and increasing downstream antioxidant protein expression (e.g., Ho-1, Gpx-1, Gclc, and Gclm), which mitigates oxidative stress in glomerular mesangial cells (GMCs) induced by high glucose

Clinical box A 22-year-old woman who took acetaminophen overdose A 22-year-old woman was admitted to hospital in a semiconscious state