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Mouzaki and Allard, 2012

A 2 L aliquot of each sample was injected into a Orbitrap Fusion Lumos (Thermo Fisher Scientific, Waltham, MA) or Orbitrap Eclipse mass spectrometer (Thermo Fisher Scientific) coupled to an UltiMate 3000 RSLCnano UHPLC system (Thermo Fisher Scientific)

None of the test monkeys suffered permanent kidney damage when dosages were managed appropriately

The STEP 1 trial, published in the New England Journal of Medicine, demonstrated 14.9 percent mean body weight reduction with the 2.4mg weekly dose over 68 weeks, compared to just 2.4 percent with placebo