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Additionally, AMPK-mediated phosphorylation of BECN1 amplifies ferroptotic signaling, positioning it as a promising target in ferroptosis-based glioblastoma therapy [73]

In conclusion, we overweigh that the main mechanism of interaction with cells is endocytosis or so-called vesicular uptake

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Whereas 4-hydroxylation constitutes the minor pathway in the liver, the greater proportion of CYP1B1 expression in extrahepatic tissues shifts the balance in favor of 4-OH-E 2 formation

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Heyland D, Muscedere J, Wischmeyer PE, Cook D, Jones G, Albert M, et al