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542 The safety of mitochondrial transplantation was evaluated in a clinical trial that included 30 patients with myocardial infarction, in which participants in the treatment group accepted autologous platelet-derived mitochondria injections into the coronary arteries, and after 40 days, the treatment group had improvements in left ventricular ejection fraction and exercise capacity, but there were no significant differences in the occurrence of adverse events such as arrhythmias and fever between the treatment and control group

PMC 393448

Oxidative stress and neuronal loss Ferroptosis, an iron-dependent form of cell death distinct from apoptosis and necrosis, is primarily triggered by oxidative stress, a key pathological process in AD

PLoS ONE 11 , e0150961 (2016)

Lack of targeting specificity Current treatments are not designed to specifically target diseased neurons

Sex bias in asthma prevalence and pathogenesis