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The ideal target should be expressed mainly, if not exclusively, on MB cells but not on healthy cells

S-nitrosylation of EAAT2 causes a decrease in transporter uptake of glutamate and an increase in glutamate in the synapse

DNA synthesis and cell division B12, through its role in the methionine synthase pathway, is indirectly involved in DNA synthesis and cell division

Again, this impairment is effectively bypassed by supplementation with gamma-glutamylcysteine, which can be transported into cells where it will be rapidly converted to GSH by GSH synthase

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