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Clinical research on polyphenol bioavailability is advancing, but large-scale intervention trials remain scarce

Dysregulated intestinal barrier integrity and gut microbiota products/metabolites play important roles in modulating ALD

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However, ellagic acid also has direct anti-androgenic effects by restricting 5-reductase, decreasing circulating testosterone levels

Thus, the participants selected in these two clinical trials may have been those with the most severe metabolic abnormalities and most expected to respond to these treatments

Various alterations have been noted in RPE cells in the presence of 7KC, such as damage to mtDNA, mitochondrial dysfunction, increased production of ROS/reactive nitrogen species (Gramajo et al., 2010), and activation of caspase-8, -12, and -3 (Neekhra et al., 2007)