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For a full overview of DSIPs mechanisms and research background, visit our main DSIP Nasal Spray page

As expected, and consistent with a reduced interaction of the amidated C-terminal tyrosine with the CTR ECD, CagriP37Y presented a lower potency than Cagri in cells expressing CTR alone (Supplementary Fig

On its own, cagrilintide showed meaningful weight loss in Phase 2 clinical trials

doi: 10.1016/B978-0-444-64181-6.00013-9 211

It completed Phase IIb clinical trials but failed to demonstrate sufficient efficacy for weight loss to secure approval

doi:10.1177/03635465241272393 Flores SE, Manatrakul R, Anigwe C, et al