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In other words, one can rephrase the famous opening line of the Anna Karenina novel by Leo Tolstoy to read: All ordered proteins are alike

The 2024 fusion-peptide work exists precisely because researchers recognized that native DSIPs delivery to the brain is the bottleneck, and engineered around it by fusing DSIP to a blood-brain-barrier-crossing TAT transduction domain (sequence GGGGYGRKKRRQRRR) via flexible GGGGS linkers, expressed and secreted from Pichia pastoris

All mice were bred in the Animal Care Facility of the University of Maryland School of Medicine and The George Washington University School of Medicine & Health Sciences