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In fact, fluid retention as a result of venous insufficiency is common, with the National Library of Medicine reporting that anywhere between 1-40% of females and 1-17% of males report suffering from venous insufficiency

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Biochem Pharmacol (2013) 86:13119

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The highest BBM expression was observed in 3% PVP and 10 M AIP, with levels 3.9 and 3.3-fold higher than control, respectively