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We confirmed the interaction between erucamide and TMEM19 by overexpressing TMEM19 in HEK293T cells and observed that overexpressed TMEM19 is prominently labeled by erucamide probes compared to control probes (Fig

The reduction in swelling also reduces the risk of further complications, such as infections or tissue damage, which are common concerns in patients with diabetic neuropathy

But specific situations call for different approaches

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Future work should further deepen research into cell death mechanisms (especially pyroptosis and ferroptosis) and inflammatory/oxidative stress pathways, refine preclinical models to better mimic human conditions, and conduct large-scale clinical cohort studies to validate potential therapies