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Adjuvant therapy can also be offered to patients in the form of general measures such as pain management, treatment of superinfections, weight loss, and smoking cessation (Figure 3) (19)

Microevolution in response to transient heme-iron restriction enhances intracellular bacterial community development and persistence

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It also upregulated the expression of multiple antioxidant defense genes (Nrf2, HO-1, TrxR-1 and xCT), playing a key role in bolstering the cells antioxidant mechanisms

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