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This finding may be associated with the treatment practice in the UK of recommending B12 supplements for Asians

Choosing folinic acid over Vitamin B12 depends on: The type of chemotherapy The patients nutritional status Genetic factors affecting nutrient use In some cases, folinic acid helps protect cells from methotrexates harm

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The paracellular translocation of macromolecules up to 125 is carried out by a low-capacity leak pathway regulated by zonula occludens (ZO), occludins, and tricellulins (Odenwald and Turner 2017