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This metabolic perturbation further indicated that elevated ROS levels upon GGCT suppression contribute to TCA cycle dysfunction

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The residues selenium-cysteine (U) or cysteine (C) at the active site, together with glutamine (Q) and tryptophan (W), forms the signature catalytic triad of the glutathione peroxidase family 30

Similarly, BRD7 exhibited a significantly higher mutation frequency in the MVI-positive group (47.5%) compared to the MVI-negative group (23.3%) (p=0.021)

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