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Metabolic changes during degeneration increase ROS production and impair mitochondrial function, causing mitochondrial fragmentation and apoptosis in NPCs (Figure 2)

No dose adjustments should be required for triazolam or other sedative hypnotics in patients cotreated with dexamethasone, given that its moderate inducer activity on CYP3A4 occurs at high doses (above 1624 mg/day) [86]

The means of different groups were compared using the Student (t) test

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