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Disruption of this regulatory circuit, as observed in PD patients with lower heart rate variability (a sign of vagal dysfunction), causes exacerbated systemic inflammation and greater microglial priming once peripheral cytokines or endotoxins reach the CNS [121]

In Africa, while IBD was historically underreported, epidemiological data now clearly indicate a rapid rise in its incidence rate across the continent, particularly in urban areas

Analysis of relative gene expression data using real-time quantitative PCR and the 2 CT method

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However, given that K a was fast (K a =24 h 1 ), larger values would not impact the model predictions and therefore considered acceptable (Fig