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Originally identified in human plasma in the early 1970s, this naturally occurring copper-binding tripeptide has since been detected in saliva and urine, suggesting a widespread and essential biological presence that acts as a cornerstone for systemic health

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For instance, Galectin-13 promotes ferroptosis spread by reducing the membrane localization of SLC7A11 in neighboring cells, a process regulated by the PKCII-FOXK1 signaling axis with interindividual variability in activity (198)

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Figure 3 shows typical chromatograms of a plasma sample spiked with AMF and WR-1065 along with the internal standard and a blank plasma sample spiked with OPA/2-ME