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19 The increased levels of ROS produced during heavy exercise must be reduced by the bodys endogenous antioxidant system in order to maintain oxidative balance

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Redox imbalance can cause an OPC maturation deficit OPCs and OLs contain exceptionally high amounts of ROS (six times as much), three times lower glutathione concentration and 20-fold higher free-iron levels than astrocytes, 106, 107 probably because their myelin synthesis entails a high metabolic rate

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SARS-CoV-2 appears to affect cellular function by altering the host Ca 2+ homeostasis in ways that promote viral infection and reproduction (see Fig

(Chen et al., 2017