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Collectively, these results documented that the interference with Ea-domain glycosylation resulted in a dramatic decrease of intracellular proIGF-1Ea level and hence proIGF-1Ea and mature IGF-1 secretion

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Other exclusion criteria were chronic renal replacement therapy (RRT), treatment limitation other than do-not-resuscitate, medical history of vasculitis, moribund (defined as an expected survival duration 30 kg/m 2 ) and non-obesity (BMI 30 kg/m 2 )

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NHS Guidance and Availability in the UK B12 injections on the NHS are available when clinically indicated for confirmed vitamin B12 deficiency

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