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21 In addition to effects on the vasculature, xanthine oxidase may have a function in end-organ damage in hypertension

however, ferrostatin-1 has low bioavailability in vivo , and its effects are not reproducible

Dysbiotic disruptions occur as consequences of critical illnesses such as cancer, cardiovascular and chronic kidney disease but also neurological, mental, and pain disorders, as well as ischemic and traumatic brain injury

Despite these advantages, peptide-based therapies face significant limitations