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Rapamycin and the recently developed more specific mTOR inhibitors, i.e., rapalogs, are promising therapeutic compounds in the treatment of cancers and several autoimmune and chronic inflammatory diseases [66]

All these patients had defects in DMEs genes and also harbored T315I kinase domain mutation already associated with nilotinib non-responsiveness in CML patients [6]

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During the pre-screening appointment, the clinician also took vital measurements, performed a physical exam, symptom, and medication review