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Curcumin and its derivatives inhibit ALK5 to down-regulate migration and invasion of cancer cells (Kandagalla et al., 2017)

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The recommended dose of ALIMTA for maintenance treatment of non-squamous NSCLC in patients with a creatinine clearance (calculated by Cockcroft-Gault equation) of 45 mL/min or greater is 500 mg/m2 as an intravenous infusion over 10 minutes on Day 1 of each 21-day cycle until disease progression or unacceptable toxicity after four cycles of platinum-based first-line chemotherapy

PubMed: 16865379 AOD 9604 Effects on Body Composition and Metabolic Parameters in Overweight Individuals with Type 2 Diabetes human rct Ng FM, Duong T, Nusser J, et al

activation of PI3K/AKT downstream pathway driving synaptogenesis and anti-apoptotic effects in hippocampus Regulatory status: not approved by the FDA or EMA

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